Amplitude modulation of androgen signaling by c-MYC
نویسندگان
چکیده
منابع مشابه
Amplitude modulation of androgen signaling by c-MYC.
Androgen-stimulated growth of the molecular apocrine breast cancer subtype is mediated by an androgen receptor (AR)-regulated transcriptional program. However, the molecular details of this AR-centered regulatory network and the roles of other transcription factors that cooperate with AR in the network remain elusive. Here we report a positive feed-forward loop that enhances breast cancer growt...
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Androgens and androgen receptors play essential roles in the development and progression of prostate cancer, a disease that claims roughly 28,000 lives annually. In addition to androgen biding, androgen receptor activity can be regulated via several post-translational modifications such as ubiquitination, acetylation, phosphorylation, methylation & SUMO-ylation. Off these modifications, phospho...
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We have developed an animal tumor model system to study the effects of c-Myc activation on apoptosis induction in vivo. Tumors were generated in SCIÃœmice from Rat-1 fibroblasts that constitutively express an inactive c-Myc-estrogen receptor fusion protein (T. D. Littlewood et al.. Nucleic Acids Res., 23: 1686-1690, 1995), which is activated in vivo by the admin istration of 4-hydroxytamoxifen ...
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Although the sebaceous gland (SG) plays an important role in skin function, the mechanisms regulating SG differentiation and carcinoma formation are poorly understood. We previously reported that c-MYC overexpression stimulates SG differentiation. We now demonstrate roles for the androgen receptor (AR) and p53. MYC-induced SG differentiation was reduced in mice lacking a functional AR. High lev...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2013
ISSN: 0890-9369
DOI: 10.1101/gad.209569.112